(19)
(11) EP 0 438 446 A1

(12)

(43) Date of publication:
31.07.1991 Bulletin 1991/31

(21) Application number: 89911189.0

(22) Date of filing: 28.09.1989
(51) International Patent Classification (IPC): 
A61K 31/ 435( . )
A61K 31/ 505( . )
A61P 9/ 00( . )
C07D 471/ 04( . )
C07D 487/ 04( . )
A61K 31/ 495( . )
A61K 31/ 55( . )
A61P 9/ 04( . )
C07D 471/ 10( . )
(86) International application number:
PCT/US1989/004265
(87) International publication number:
WO 1990/003790 (19.04.1990 Gazette 1990/09)
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE

(30) Priority: 11.10.1988 US 19880255728
11.10.1988 US 19880255749

(71) Applicant: RORER INTERNATIONAL (OVERSEAS) INC
Wilmington, DE 19810 (US)

(72) Inventors:
  • SPADA, Alfred, Paul
    Ambler, PA 19002 (US)
  • STUDT, William, Lyon
    Harleysville, PA 19438 (US)
  • CAMPBELL, Henry, Flud
    North Wales, PA 19454 (US)
  • KUHLA, Donald, Ernest
    Doylestown, PA 18901 (US)
  • TUCKER, Thomas
    North Wales, PA 19454 (US)

(74) Representative: Le Pennec, Magali, et al 
RHONE-POULENC RORER SA, Direction des Brevets, 20 Avenue Raymond Aron
F-92160 Antony
F-92160 Antony (FR)

   


(54) PYRIDAZINONE-, PYRAZOLONE- AND PYRIDONE-NAPHTHERIDINONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING SAME, AND THEIR USES