(19)

(11)

EP 0 439 553 A1

(12)

(43) Date of publication: 07.08.1991 Bulletin 1991/32 (21) Application number: 89913146.0 (22) Date of filing: 17.11.1989

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C12N 15/ 09( . ) C07K 14/ 47( . ) C12N 15/ 85( . ) (86) International application number: PCT/US1989/005055 (87) International publication number: WO 1990/006367 (14.06.1990 Gazette 1990/14)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 30.11.1988 US 19880277752 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)	(72) Inventors: MCNAB, Alistair, R. Portage, MI 49002 (US) WOOD, Linda, S. Kalamazoo, MI 49001 (US) VOGELI, Gabriel Kalamazoo, MI 49008 (US) KAYTES, Paul, S. Kalamazoo, MI 49008 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)