(19)

(11)

EP 0 439 607 A1

(12)

(43) Date of publication: 07.08.1991 Bulletin 1991/32 (21) Application number: 90917850.0 (22) Date of filing: 27.06.1990

(51) International Patent Classification (IPC):  C07D 321/ 10( . ) A01N 43/ 90( . ) A01N 43/ 24( . ) C07D 407/ 12( . ) (86) International application number: PCT/US1990/003672 (87) International publication number: WO 1991/000009 (10.01.1991 Gazette 1991/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 29.06.1989 US 19890373210 25.06.1990 US 19900542563 (71) Applicant: ISK BIOSCIENCES CORPORATION Mentor, OH 44061-8000 (US)	(72) Inventors: BARNES, Keith, D. Newtown, PA 18940 (US) HOTZMAN, Frederick, W. Morrisville, PA 19067 (US) LIMPEL, Lawrence, E. Euclid, OH 44123 (US) MAGEE, Thomas, A. Mentor, OH 44060 (US) (74) Representative: Crampton, Keith John Allen, et al  D. YOUNG & CO. 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)