(19)

(11)

EP 0 440 606 A1

(12)

(43) Date of publication: 14.08.1991 Bulletin 1991/33 (21) Application number: 89900817.0 (22) Date of filing: 16.12.1988

(51) International Patent Classification (IPC):  A61K 49/ 00( . ) A61K 49/ 06( . ) C07D 257/ 02( . ) A61K 49/ 04( . ) A61K 51/ 00( . ) (86) International application number: PCT/EP1988/001166 (87) International publication number: WO 1989/005802 (29.06.1989 Gazette 1989/14)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.12.1987 IT 19870023217 (71) Applicant: BRACCO INDUSTRIA CHIMICA Società per Azioni I-20134 Milano (IT)	(72) Inventors: FELDER, Ernst I-20134 Milano (IT) MUSU, Carlo I-20134 Milano (IT) FUMAGALLI, Luciano I-20134 Milano (IT) UGGERI, Fulvio I-20134 Milano (IT) (74) Representative: Minoja, Fabrizio  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milano I-20122 Milano (IT)