(19)

(11)

EP 0 440 611 A1

(12)

(43) Date of publication: 14.08.1991 Bulletin 1991/33 (21) Application number: 89901717.0 (22) Date of filing: 03.01.1989

(51) International Patent Classification (IPC):  C12Q 1/ 28( . ) G01N 33/ 58( . ) (86) International application number: PCT/GB1989/000015 (87) International publication number: WO 1989/006362 (13.07.1989 Gazette 1989/15)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 08.01.1988 GB 19880000373 (71) Applicant: University of Wales College of Medicine Cardiff CF4 4XN (GB)	(72) Inventor: MORGAN, John, Michael Cardiff South Glamorgan (GB) (74) Representative: Austin, Hedley William, et al  Urquhart-Dykes & Lord Alexandra House 1 Alexandra Road Swansea West Glamorgan SA1 5ED Swansea West Glamorgan SA1 5ED (GB)