(19)

(11)

EP 0 440 750 A1

(12)

(43) Date of publication: 14.08.1991 Bulletin 1991/33 (21) Application number: 90900660.0 (22) Date of filing: 13.12.1989

(51) International Patent Classification (IPC):  C07K 14/ 47( . ) G01N 33/ 60( . ) G01N 33/ 50( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1989/005560 (87) International publication number: WO 1990/007122 (28.06.1990 Gazette 1990/15)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 14.12.1988 US 19880284212 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: ROBERTS, James, M. Mill Valley, CA 94941 (US) TAYLOR, Robert, N. San Francisco, CA 94127 (US) (74) Representative: Thomson, Paul Anthony  Potts, Kerr & Co. 15, Hamilton Square Birkenhead Merseyside L41 6BR Birkenhead Merseyside L41 6BR (GB)