| (19) |
 |
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(11) |
EP 0 443 532 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
26.02.1992 Bulletin 1992/09 |
| (43) |
Date of publication A2: |
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28.08.1991 Bulletin 1991/35 |
| (22) |
Date of filing: 19.02.1991 |
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| (84) |
Designated Contracting States: |
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AT BE CH DE DK ES FR GB GR IT LI LU NL SE |
| (30) |
Priority: |
20.02.1990 US 482428
|
| (71) |
Applicant: SYNTEX (U.S.A.) INC. |
|
Palo Alto
California 94304 (US) |
|
| (72) |
Inventors: |
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- Nestor, John J., Jr.
Cupertino, CA 95014 (US)
- McClure, Natalie L.
Portola Valley, CA 94028 (US)
|
| (74) |
Representative: Barz, Peter, Dr. et al |
|
Patentanwälte Dipl.-Ing. G. Dannenberg
Dr. P. Weinhold, Dr. D. Gudel
Dipl.-Ing. S. Schubert, Dr. P. Barz
Siegfriedstrasse 8
80803 München
80803 München (DE) |
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| |
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| (54) |
Temporary minimal protection synthesis of LH-RH analogs |
(57) A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine,
if present, are side chain protected during the synthesis with groups labile to selected
α-amino or deprotecting agents.