(19)
(11) EP 0 443 532 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
26.02.1992 Bulletin 1992/09

(43) Date of publication A2:
28.08.1991 Bulletin 1991/35

(21) Application number: 91102370.3

(22) Date of filing: 19.02.1991
(51) International Patent Classification (IPC)5C07K 7/20, A61K 37/43
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 20.02.1990 US 482428

(71) Applicant: SYNTEX (U.S.A.) INC.
Palo Alto California 94304 (US)

(72) Inventors:
  • Nestor, John J., Jr.
    Cupertino, CA 95014 (US)
  • McClure, Natalie L.
    Portola Valley, CA 94028 (US)

(74) Representative: Barz, Peter, Dr. et al
Patentanwälte Dipl.-Ing. G. Dannenberg Dr. P. Weinhold, Dr. D. Gudel Dipl.-Ing. S. Schubert, Dr. P. Barz Siegfriedstrasse 8
80803 München
80803 München (DE)


(56) References cited: : 
   
       


    (54) Temporary minimal protection synthesis of LH-RH analogs


    (57) A solid phase synthesis of LH-RH analogs in which the amino acids serine and histidine, if present, are side chain protected during the synthesis with groups labile to selected α-amino or deprotecting agents.





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