(19)

(11)

EP 0 444 156 A1

(12)

(43) Date of publication: 04.09.1991 Bulletin 1991/36 (21) Application number: 90901238.0 (22) Date of filing: 20.11.1989

(51) International Patent Classification (IPC):  C07D 211/ 76( . ) A61K 38/ 55( . ) A61P 3/ 08( . ) A61P 15/ 00( . ) C07D 211/ 46( . ) C07D 417/ 06( . ) C07K 5/ 02( . ) A61K 38/ 00( . ) A61K 45/ 00( . ) A61P 13/ 02( . ) A61P 27/ 02( . ) C07D 417/ 04( . ) C07D 417/ 14( . ) C07K 5/ 078( . ) (86) International application number: PCT/US1989/005248 (87) International publication number: WO 1990/005531 (31.05.1990 Gazette 1990/12)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL SE (30) Priority: 21.11.1988 US 19880275151 (71) Applicant: ABBOTT LABORATORIES Abbott Park, IL 60064-2204 (US)	(72) Inventor: KLEINERT, Hollis, D. Buffalo Grove, IL 60089 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano & Associati S.r.l. Via Meravigli, 16 I-20123 Milano I-20123 Milano (IT)