(19)

(11)

EP 0 445 218 A1

(12)

(43) Date of publication: 11.09.1991 Bulletin 1991/37 (21) Application number: 90901107.0 (22) Date of filing: 11.10.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 5/ 10( . ) C12N 15/ 113( . ) A61K 35/ 12( . ) C12N 9/ 02( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1989/004569 (87) International publication number: WO 1990/005781 (31.05.1990 Gazette 1990/12)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.11.1988 US 19880275283 (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventor: LAM, Dominic, M. The Woodlands, TX 77381 (US) (74) Representative: Harrison, David Christopher, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)