(19)
(11) EP 0 445 948 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
07.10.1992 Bulletin 1992/41

(43) Date of publication A2:
11.09.1991 Bulletin 1991/37

(21) Application number: 91301546.7

(22) Date of filing: 26.02.1991
(51) International Patent Classification (IPC)5: A61K 31/557
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 28.02.1990 GB 9004482

(71) Applicant: G.D. Searle & Co.
Chicago Illinois 60680 (US)

(72) Inventors:
  • Shield Michael
    Buckinghamshire HP 17 8PR (GB)
  • Dingle John
    Great Shelford,Cambridge, CB2 5EL (GB)

(74) Representative: Goldin, Douglas Michael et al
J.A. KEMP & CO. 14, South Square Gray's Inn
London WC1R 5LX
London WC1R 5LX (GB)


(56) References cited: : 
   
       


    (54) Prostaglandins for inhibiting cartilage damage


    (57) Misoprostol is used in the preparation of a medicament to inhibit cartilage damage, to reverse inhibition of cartilage synthesis, to inhibit the damaging effect of IL1 on cartilage integrity by direct damage or to inhibit cartilage synthesis.






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