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(11)

EP 0 447 484 A1

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(43) Date of publication: 25.09.1991 Bulletin 1991/39 (21) Application number: 90901236.0 (22) Date of filing: 24.11.1989

(51) International Patent Classification (IPC):  C07D 215/ 22( . ) A61K 31/ 47( . ) C07D 215/ 56( . ) C07D 413/ 04( . ) C07D 471/ 04( . ) C07D 487/ 08( . ) A61K 31/ 435( . ) A61K 31/ 535( . ) C07D 401/ 04( . ) C07D 417/ 04( . ) C07D 471/ 08( . ) C07D 519/ 00( . ) (86) International application number: PCT/US1989/005213 (87) International publication number: WO 1990/006307 (14.06.1990 Gazette 1990/14)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 06.12.1988 US 19880280603 22.03.1989 US 19890326907 07.04.1989 US 19890335163 22.05.1989 US 19890355016 25.09.1989 US 19890411449 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)

(72) Inventors: GAMMILL, Ronald, B. Kalamazoo, MI 49002 (US) BISAHA, Sharon, N. Lawton, MI 49065 (US) TIMKO, Joseph, M. Vicksburg, MI 49097 (US) JUDGE, Thomas, M. Kalamazoo, MI 49001 (US) BARBACHYN, Michael, R. Kalamazoo, MI 49001 (US) KIM, Kyoung, S. Lawrenceville, NJ 08648 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)