(19)

(11)

EP 0 448 632 A1

(12)

(43) Date of publication: 02.10.1991 Bulletin 1991/40 (21) Application number: 90901337.0 (22) Date of filing: 08.12.1989

(51) International Patent Classification (IPC):  G01N 33/ 536( . ) G01N 33/ 543( . ) G01N 33/ 68( . ) G01N 33/ 541( . ) G01N 33/ 577( . ) (86) International application number: PCT/US1989/005569 (87) International publication number: WO 1990/006515 (14.06.1990 Gazette 1990/14)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 09.12.1988 US 19880281992 (71) Applicant: CENTOCOR, INC. Malvern, PA 19355 (US)	(72) Inventor: LoBUGLIO, Albert, F. Birmingham, AL 35294 (US) (74) Representative: Harvey, David Gareth, et al  Graham Watt & Co. Riverhead Sevenoaks Kent TN13 2BN Sevenoaks Kent TN13 2BN (GB)