(19)
(11) EP 0 451 211 A1

(12)

(43) Date of publication:
16.10.1991 Bulletin 1991/42

(21) Application number: 90902086.0

(22) Date of filing: 29.12.1989
(51) International Patent Classification (IPC): 
A61K 38/ 00( . )
A61M 25/ 00( . )
A61P 9/ 08( . )
A61P 17/ 00( . )
A61P 35/ 00( . )
C07K 14/ 505( . )
C07K 14/ 525( . )
C07K 14/ 535( . )
C07K 14/ 555( . )
C07K 14/ 755( . )
C07K 14/ 78( . )
C12N 1/ 21( . )
C12N 15/ 12( . )
G01N 33/ 53( . )
 A61K 49/ 00( . )
A61P 7/ 02( . )
A61P 9/ 10( . )
A61P 31/ 04( . )
C07K 14/ 00( . )
C07K 14/ 52( . )
C07K 14/ 53( . )
C07K 14/ 54( . )
C07K 14/ 745( . )
C07K 14/ 76( . )
C07K 19/ 00( . )
C12N 15/ 09( . )
C12P 21/ 02( . )
C12R 1/ 19( . )
(86) International application number:
PCT/US1989/005875
(87) International publication number:
WO 1990/007577 (12.07.1990 Gazette 1990/16)
(84) Designated Contracting States:
AT BE CH DE ES FR GB IT LI LU NL SE

(30) Priority: 29.12.1988 US 19880291951
28.04.1989 US 19890345952

(71) Applicants:
  • BIO-TECHNOLOGY GENERAL CORPORATION
    New York NY 10001 (US)
  • VOGEL, Tikva
    76 100 Rehovot (IL)
  • LEVANON, Avigdor
    76 100 Rehovot (IL)
  • WERBER, Moshe
    61 999 TEL Aviv (IL)
  • GUY, Rachel
    76 100 Rehovot (IL)
  • PANET, Amos
    91 999 Jerusalem (IL)

(72) Inventors:
  • Vogel, Tikva
    76 100 Rehovot (IL)
  • Levanon, Avigdor
    76 100 Rehovot (IL)
  • Werber, Moshe
    61 999 Tel Aviv (IL)
  • Guy, Rachel
    76 100 Rehovot (IL)
  • Panet, Amos
    91999 Jerusalem (IL)

(74) Representative: Henkel, Feiler, Hänzel & Partner 
Möhlstrasse 37
D-81675 München
D-81675 München (DE)

   


(54) CLONING AND PRODUCTION OF POLYPEPTIDE ANALOGS OF HUMAN FIBRONECTIN AND METHOD OF USING SUCH POLYPEPTIDE ANALOGS