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(11)

EP 0 452 447 A1

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(43) Date of publication: 23.10.1991 Bulletin 1991/43 (21) Application number: 90915774.0 (22) Date of filing: 02.11.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 1/ 06( . ) C07K 7/ 08( . ) A61P 35/ 00( . ) C07K 7/ 06( . ) (86) International application number: PCT/EP1990/001836 (87) International publication number: WO 1991/006563 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 06.11.1989 GB 19890025024 22.03.1990 GB 19900006413 (71) Applicant: FARMITALIA CARLO ERBA S.r.l. I-20159 Milano (IT)

(72) Inventors: DE CASTIGLIONE, Roberto I-20149 Milan (IT) GOZZINI, Luigia I-20159 Milan (IT) CORRADI, Fabio I-20122 Milan (IT) CIOMEI, Marina I-27020 Torre d'Isola (IT) MOLINARI, Isabella I-20144 Milan (IT) FRANZETTI, Cristina I-20154 Milan (IT) (74) Representative: Kolb, Helga, Dr. Dipl.-Chem., et al  Hoffmann, Eitle & Partner, Patentanwälte, Postfach 81 04 20 D-81904 München D-81904 München (DE)