(19)

(11)

EP 0 454 730 A1

(12)

(43) Date of publication: 06.11.1991 Bulletin 1991/45 (21) Application number: 90901997.0 (22) Date of filing: 11.12.1989

(51) International Patent Classification (IPC):  A23K 1/ 165( . ) C07K 14/ 575( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 38/ 27( . ) C07K 14/ 61( . ) C12N 15/ 18( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1989/005447 (87) International publication number: WO 1990/008164 (26.07.1990 Gazette 1990/17)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 19.01.1989 US 19890299107 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)	(72) Inventors: GARLICK, Robert, L. Augusta, MI 49012 (US) LYLE, Stephen, B. Kalamazoo, MI 49001 (US) MOTT, John, E. Kalamazoo, MI 49001 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)