(19)

(11)

EP 0 454 820 A1

(12)

(43) Date of publication: 06.11.1991 Bulletin 1991/45 (21) Application number: 90916854.0 (22) Date of filing: 26.10.1990

(51) International Patent Classification (IPC):  A01N 43/ 22( . ) C07H 17/ 08( . ) C12R 1/ 01( . ) C07H 1/ 08( . ) C12P 19/ 62( . ) (86) International application number: PCT/US1990/006187 (87) International publication number: WO 1991/006552 (16.05.1991 Gazette 1991/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 30.10.1989 US 19890429441 15.12.1989 US 19890451394 (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventor: BAKER, Patrick, James Greenwood, IN 46142 (US) (74) Representative: Raynor, John, et al  W.H. Beck, Greener & Co 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)