(19)

(11)

EP 0 456 642 A1

(12)

(43) Date of publication: 21.11.1991 Bulletin 1991/47 (21) Application number: 90901301.0 (22) Date of filing: 11.12.1989

(51) International Patent Classification (IPC):  C12P 21/ 02( . ) C07K 14/ 61( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) A23K 1/ 165( . ) C12N 1/ 21( . ) C12N 15/ 18( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1989/005445 (87) International publication number: WO 1990/008823 (09.08.1990 Gazette 1990/19)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 31.01.1989 US 19890304733 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, MI 49001 (US)	(72) Inventors: PARCELLS, Alan, J. Portage, MI 49002 (US) MOTT, John, E. Kalamazoo, MI 49004 (US) TOMICH, Che-Shen, C. Kalamazoo, MI 49008 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)