(19)

(11)

EP 0 456 739 A1

(12)

(43) Date of publication: 21.11.1991 Bulletin 1991/47 (21) Application number: 90903084.0 (22) Date of filing: 02.02.1990

(51) International Patent Classification (IPC):  G01N 1/ 02( . ) G01N 33/ 497( . ) G01N 1/ 40( . ) A61B 5/ 083( . ) G01N 1/ 22( . ) (86) International application number: PCT/US1990/000584 (87) International publication number: WO 1990/009572 (23.08.1990 Gazette 1990/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 02.02.1989 US 19890305286 11.01.1990 US 19900463574 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventor: GLASER, Robert, A. Cincinnati, OH 45237 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)