(19)
(11) EP 0 457 875 A1

(12)

(43) Date of publication:
27.11.1991 Bulletin 1991/48

(21) Application number: 91900650.0

(22) Date of filing: 13.11.1990
(51) International Patent Classification (IPC): 
G01N 33/ 574( . )
A61K 47/ 48( . )
A61K 51/ 10( . )
C07K 14/ 00( . )
C07K 16/ 30( . )
C07K 19/ 00( . )
C12N 1/ 21( . )
G01N 33/ 577( . )
C12R 1/ 19( . )
 A61K 39/ 395( . )
A61K 49/ 00( . )
C07K 1/ 22( . )
C07K 16/ 00( . )
C07K 16/ 46( . )
C12N 1/ 19( . )
C12P 21/ 08( . )
A61K 38/ 00( . )
C12R 1/ 865( . )
(86) International application number:
PCT/US1990/006620
(87) International publication number:
WO 1991/007418 (30.05.1991 Gazette 1991/12)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 13.11.1989 US 19890435012

(71) Applicants:
  • Xoma Corporation
    Berkeley California 94710 (US)
  • THE GREEN CROSS CORPORATION
    Osaka-shi Osaka 541 (JP)

(72) Inventors:
  • BETTER, Marc, D.
    Los Angeles, CA 90046 (US)
  • HORWITZ, Arnold, H.
    Los Angeles, CA 90045 (US)
  • LEI, Shau-Ping
    Los Angeles, CA 90064 (US)
  • ROBINSON, Randy, R.
    Los Angeles, CA 90045 (US)

(74) Representative: Sheard, Andrew Gregory, et al 
Kilburn & Strode 30, John Street
London WC1N 2DD
London WC1N 2DD (GB)

   


(54) CHIMERIC MOUSE-HUMAN A10 ANTIBODY WITH SPECIFICITY TO A HUMAN TUMOR CELL ANTIGEN