(19)

(11)

EP 0 458 835 A1

(12)

(43) Date of publication: 04.12.1991 Bulletin 1991/49 (21) Application number: 90903196.0 (22) Date of filing: 15.02.1990

(51) International Patent Classification (IPC):  A61K 9/ 20( . ) A61K 9/ 22( . ) A61K 9/ 52( . ) A61K 9/ 00( . ) A61K 9/ 48( . ) (86) International application number: PCT/GB1990/000250 (87) International publication number: WO 1990/009169 (23.08.1990 Gazette 1990/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 16.02.1989 GB 19890003564 (71) Applicant: NATIONAL RESEARCH DEVELOPMENT CORPORATION London SE1 6BU (GB)	(72) Inventor: RASHID, Abdul Glasgow G41 3AU (GB) (74) Representative: Hamilton, Raymond, et al  Patents Department British Technology Group Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)