(19)

(11)

EP 0 460 064 A1

(12)

(43) Date of publication: 11.12.1991 Bulletin 1991/50 (21) Application number: 90904101.0 (22) Date of filing: 21.02.1990

(51) International Patent Classification (IPC):  A61K 9/ 12( . ) A61K 9/ 14( . ) A61K 38/ 00( . ) A61K 47/ 06( . ) A61K 9/ 00( . ) A61K 9/ 72( . ) A61K 38/ 23( . ) C07K 14/ 585( . ) (86) International application number: PCT/US1990/000928 (87) International publication number: WO 1990/009781 (07.09.1990 Gazette 1990/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 23.02.1989 US 19890314605 (71) Applicant: RORER INTERNATIONAL (HOLDINGS) INC. Lewes, Delaware 19958 (US)	(72) Inventors: FELT, George, Robert 1485 Ashford Avenue Box 1003 Condada, PR 00907 (US) WARCHOL, Mark, Peter Ambler, PA 19002 (US) (74) Representative: Le Pennec, Magali, et al  RHONE-POULENC RORER SA, Direction des Brevets, 20 Avenue Raymond Aron F-92165 Antony Cédex F-92165 Antony Cédex (FR)