(19)

(11)

EP 0 462 111 A1

(12)

(43) Date of publication: 27.12.1991 Bulletin 1991/52 (21) Application number: 90902104.0 (22) Date of filing: 10.11.1989

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 37/ 00( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) C12P 21/ 08( . ) A61K 39/ 395( . ) C07H 21/ 04( . ) C07K 14/ 705( . ) C07K 16/ 28( . ) C12N 15/ 09( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1989/005067 (87) International publication number: WO 1990/007321 (12.07.1990 Gazette 1990/16)

(84) Designated Contracting States: CH DE FR GB LI (30) Priority: 23.12.1988 US 19880289201 24.02.1989 US 19890315736 (71) Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Stanford California 94305 (US)	(72) Inventors: WEISSMAN, Irving, L. Stanford, CA 94305 (US) HOLZMANN, Bernard D-8000 Münich 90 (DE) SIEGELMAN, Mark, H. Palo Alto, CA 94306 (US) (74) Representative: Harrison, David Christopher  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)