(19)
(11)
EP 0 463 037 A1
(12)
(43)
Date of publication:
02.01.1992
Bulletin 1992/01
(21)
Application number:
90904716.0
(22)
Date of filing:
15.03.1990
(51)
International Patent Classification (IPC):
C12N
15/
09
( . )
A61K
38/
21
( . )
A61K
39/
00
( . )
A61K
39/
395
( . )
A61P
35/
00
( . )
A61P
43/
00
( . )
C07K
14/
505
( . )
C07K
14/
53
( . )
C07K
14/
54
( . )
C07K
14/
55
( . )
C07K
16/
00
( . )
C12N
15/
12
( . )
C12R
1/
91
( . )
A61K
38/
00
( . )
A61K
38/
22
( . )
A61K
39/
39
( . )
A61P
31/
04
( . )
A61P
37/
04
( . )
C07K
14/
00
( . )
C07K
14/
52
( . )
C07K
14/
535
( . )
C07K
14/
545
( . )
C07K
14/
555
( . )
C12N
5/
10
( . )
C12P
21/
02
( . )
(86)
International application number:
PCT/US1990/001355
(87)
International publication number:
WO 1990/011301
(
04.10.1990
Gazette 1990/23)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB IT LI LU NL SE
(30)
Priority:
17.03.1989
US 19890325408
(71)
Applicants:
GENETICS INSTITUTE, INC.
Cambridge, MA 02140 (US)
BRIGHAM AND WOMEN'S HOSPITAL
Boston, Massachusetts 02115 (US)
(72)
Inventors:
CLARK, Steven, C.
Winchester, MA 01890 (US)
WEISER, Weishui
Concord, MA 01742 (US)
(74)
Representative:
VOSSIUS & PARTNER
Postfach 86 07 67
D-81634 München
D-81634 München (DE)
(54)
HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR