| (19) |
 |
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(11) |
EP 0 463 644 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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19.11.1992 Bulletin 1992/47 |
| (43) |
Date of publication A2: |
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02.01.1992 Bulletin 1992/01 |
| (22) |
Date of filing: 25.07.1987 |
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| (84) |
Designated Contracting States: |
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AT BE CH DE ES FR GB GR IT LI LU NL SE |
| (30) |
Priority: |
04.08.1986 US 893136
27.08.1986 US 900930
15.06.1987 US 57709
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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87110801.5 / 0258616 |
| (71) |
Applicant: NYCOMED SALUTAR, INC. |
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Sunnyvale,
California 94086 (US) |
|
| (72) |
Inventors: |
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- Kraft, Karl F.,
c/o Salutar Inc.
Sunnyvale, CA 94086 (US)
- Quay, Steven Carl,
c/o Salutar Inc.
Sunnyvale, CA 94086 (US)
- Rocklage, Scott M.
Los Gatos, CA 95032 (US)
- Worah, Dilip M.
Menlo Park, CA 94025 (US)
|
| (74) |
Representative: Cockbain, Julian, Dr. et al |
|
Frank B. Dehn & Co.
Imperial House
15-19 Kingsway
London WC2B 6UZ
London WC2B 6UZ (GB) |
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| |
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|
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Remarks: |
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This application was filed on 20 - 09 - 1991 as a divisional application to the application
mentioned under INID code 60. |
|
| (54) |
Use of chelate complexes |
(57) The disclosure provides the use of a physiologically compatible chelate complex of
a chelating compound and a paramagnetic ion of a lanthanide element having an atomic
number in the range 57 to 70 or of a transition metal having an atomic number selected
from 21 to 29, 42 and 44 and of a non-paramagnetic organic calcium salt for the preparation
of a magnetic resonance imaging contrast medium by admixture of said complex and said
organic salt. The admixed calcium serves to enhance the biotolerability of the paramagnetic
chelate containing MRI contrast medium.