(19)

(11)

EP 0 465 557 A1

(12)

(43) Date of publication: 15.01.1992 Bulletin 1992/03 (21) Application number: 90905844.0 (22) Date of filing: 26.03.1990

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) C12Q 1/ 70( . ) (86) International application number: PCT/US1990/001533 (87) International publication number: WO 1990/011373 (04.10.1990 Gazette 1990/23)

(84) Designated Contracting States: AT BE DE DK FR GB IT LU NL SE (30) Priority: 27.03.1989 US 19890329142 (71) Applicant: E.I. DU PONT DE NEMOURS AND COMPANY Wilmington Delaware 19898 (US)	(72) Inventors: HOBBS, Frank, Worden, Jr. Wilmington, DE 19803 (US) LITT, Gerald, Joseph Wellesley, MA 02181 (US) MILLER, Jeffrey, Allan Derry, NH 03038 (US) (74) Representative: Myerscough, Philip Boyd, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)