(19)

(11)

EP 0 467 972 A1

(12)

(43) Date of publication: 29.01.1992 Bulletin 1992/05 (21) Application number: 90906659.0 (22) Date of filing: 30.03.1990

(51) International Patent Classification (IPC):  A61K 39/ 00( . ) C07K 14/ 00( . ) C07K 14/ 195( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 53( . ) C12R 1/ 19( . ) C12R 1/ 91( . ) A61K 39/ 02( . ) C07K 14/ 005( . ) C07K 14/ 29( . ) C12N 15/ 02( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) G01N 33/ 569( . ) C12R 1/ 90( . ) (86) International application number: PCT/US1990/001678 (87) International publication number: WO 1990/012030 (18.10.1990 Gazette 1990/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 06.04.1989 US 19890335178 (71) Applicant: WASHINGTON STATE UNIVERSITY RESEARCH FOUNDATION, INC. Pullman, WA 99164-1802 (US)

(72) Inventors: McGUIRE, Travis, Clinton Pullman, WA 99163 (US) PALMER, Guy, Hughes Pullman, WA 99163 (US) BARBET, Anthony, Francis Archer, FL 32618 (US) DAVIS, William, Charles Pullman, WA 99163 (US) ALLRED, David, Redding Gainesville, FL 32605 (US) (74) Representative: Tyrrell, Arthur William Russell, Dr.  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)