(19)

(11)

EP 0 470 165 A1

(12)

(43) Date of publication: 12.02.1992 Bulletin 1992/07 (21) Application number: 90907285.0 (22) Date of filing: 26.04.1990

(51) International Patent Classification (IPC):  A61K 38/ 16( . ) C07K 14/ 00( . ) C07K 14/ 49( . ) C07K 14/ 73( . ) C07K 14/ 755( . ) C07K 14/ 765( . ) C07K 14/ 81( . ) C12N 1/ 19( . ) C12N 15/ 09( . ) C12N 15/ 81( . ) A61K 38/ 00( . ) C12R 1/ 865( . ) A61P 43/ 00( . ) C07K 14/ 47( . ) C07K 14/ 52( . ) C07K 14/ 745( . ) C07K 14/ 76( . ) C07K 14/ 78( . ) C07K 19/ 00( . ) C12N 1/ 21( . ) C12N 15/ 62( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1990/000650 (87) International publication number: WO 1990/013653 (15.11.1990 Gazette 1990/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 29.04.1989 GB 19890009916 (71) Applicant: Delta Biotechnology Limited Nottingham NG7 1FD (GB)	(72) Inventor: BALLANCE, David James West Bridgford, Nottingham NG2 7AG (GB) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)