(19)

(11)

EP 0 471 687 A1

(12)

(43) Date of publication: 26.02.1992 Bulletin 1992/09 (21) Application number: 90906539.0 (22) Date of filing: 04.04.1990

(51) International Patent Classification (IPC):  C07K 14/ 195( . ) C12N 9/ 10( . ) C12N 15/ 31( . ) C12N 15/ 72( . ) C12N 1/ 21( . ) C12N 9/ 88( . ) C12N 15/ 52( . ) C12N 15/ 74( . ) (86) International application number: PCT/US1990/001811 (87) International publication number: WO 1990/012098 (18.10.1990 Gazette 1990/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 12.04.1989 US 19890337194 23.03.1990 US 19900496236 (71) Applicant: CETUS CORPORATION Emeryville California 94608 (US)

(72) Inventors: BEN-BASSAT, Arie Walnut Creek, CA 94598 (US) CALHOON, Roger, D. Concord, CA 94518 (US) FEAR, Anna, Lisa Oakland, CA 94611 (US) GELFAND, David, H. Oakland, CA 94611 (US) MEADE, James, H. Pinole, CA 94564 (US) TAL, Rony Richmond, CA 94805 (US) WONG, Hing San Ramon, CA 94585 (US) BENSIMAN, Moshe 91 999 Jerusalem (IL) (74) Representative: Bizley, Richard Edward, et al  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Bakers Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)