(19)

(11)

EP 0 471 790 A1

(12)

(43) Date of publication: 26.02.1992 Bulletin 1992/09 (21) Application number: 90908791.0 (22) Date of filing: 02.05.1990

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) A61K 51/ 06( . ) A61K 49/ 08( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1990/002458 (87) International publication number: WO 1990/013256 (15.11.1990 Gazette 1990/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 04.05.1989 US 19890347358 (71) Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION Madison, WI 53707-7365 (US)	(72) Inventors: KORNGUTH, Steven Madison, WI 53705 (US) TURSKI, Patrick Madison, WI 53705 (US) ROBINS, H., Ian Madison, WI 53705 (US) NICKLES, Robert, J. Madison, WI 53705 (US) (74) Representative: Ellis-Jones, Patrick George Armine, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)