(19)

(11)

EP 0 471 832 A1

(12)

(43) Date of publication: 26.02.1992 Bulletin 1992/09 (21) Application number: 91906376.0 (22) Date of filing: 22.02.1991

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) C12N 9/ 72( . ) C12N 15/ 85( . ) C12P 21/ 00( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) C12N 15/ 90( . ) (86) International application number: PCT/US1991/001222 (87) International publication number: WO 1991/013151 (05.09.1991 Gazette 1991/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 22.02.1990 US 19900483450 (71) Applicant: BIOGEN, INC. Cambridge Massachusetts 02142 (US)	(72) Inventor: MEADE, Harry Newton, MA 02158 (US) (74) Representative: Bannerman, David Gardner  Withers & Rogers 9 The Parade Leamington Spa Warwickshire CV32 5DG Leamington Spa Warwickshire CV32 5DG (GB)