(19)
(11) EP 0 472 060 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
19.08.1992 Bulletin 1992/34

(43) Date of publication A2:
26.02.1992 Bulletin 1992/09

(21) Application number: 91113363.5

(22) Date of filing: 08.08.1991
(51) International Patent Classification (IPC)5: C07D 501/46, C07D 501/22, C07D 501/24, A61K 31/545
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IT LI LU NL SE

(30) Priority: 23.08.1990 US 572517

(71) Applicant: Bristol-Myers Squibb Company
New York, N.Y. 10154 (US)

(72) Inventors:
  • Tajaaki, Okita
    Itabashi-ku, Tokyo (JP)
  • Hajime, Kamachi
    Urayasu (JP)
  • Shinji, Masuyoshi
    Sayama (JP)
  • Kiyoto, Imae
    Kawasaki (JP)

(74) Representative: Kinzebach, Werner, Dr. et al
Patentanwälte Reitstötter, Kinzebach und Partner Postfach 86 06 49
D-81633 München
D-81633 München (DE)


(56) References cited: : 
   
       


    (54) Antibiotic c-7 catechol-subtituted cephalosporin compounds, compositions, and use thereof


    (57) The present invention relates to new cephalosporins of the formula


    wherein
       R¹ and R² are hydrogen or carboxy, with the proviso that both cannot be the same;
       R³ is hydrogen or acetyl; and
       R⁴ is a radical selected from the group consisting of


    or -CH=CH-CH₂-R⁶
    in which n is 1 or 2, R⁵ is hydrogen or acetyl, and R⁶ is hydrogen, a lower C₁₋₃ alkyl, or a radical selected from the group consisting of


    in which n and R⁵ are as defined above.
    In another aspect, this invention relates to processes for the preparation of the compounds of Formula I, to pharmaceutical compositions containing at least one compound of Formula I, and to intermediates in their preparation.





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