(19)

(11)

EP 0 472 595 A1

(12)

(43) Date of publication: 04.03.1992 Bulletin 1992/10 (21) Application number: 90907735.0 (22) Date of filing: 15.05.1990

(51) International Patent Classification (IPC):  C07D 405/ 04( . ) A61K 31/ 505( . ) A61K 31/ 00( . ) A61P 1/ 16( . ) (86) International application number: PCT/US1990/002685 (87) International publication number: WO 1990/014079 (29.11.1990 Gazette 1990/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 15.05.1989 US 19890351519 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventors: HOOFNAGLE, Jay, H. Rockville, MD 20852 (US) BRODER, Samuel Bethesda, MD 20814 (US) MITSUYA, Hiroaki Rockville, MD 20852 (US) YARCHOAN, Robert Bethesda, MD 20817 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)