(19)

(11)

EP 0 472 639 A1

(12)

(43) Date of publication: 04.03.1992 Bulletin 1992/10 (21) Application number: 90908748.0 (22) Date of filing: 15.05.1990

(51) International Patent Classification (IPC):  A61K 9/ 127( . ) A61K 31/ 165( . ) A61K 31/ 435( . ) A61K 31/ 49( . ) A61K 31/ 55( . ) A61K 47/ 24( . ) A61K 31/ 135( . ) A61K 31/ 415( . ) A61K 31/ 47( . ) A61K 31/ 54( . ) A61K 45/ 00( . ) (86) International application number: PCT/US1990/002736 (87) International publication number: WO 1990/014105 (29.11.1990 Gazette 1990/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 15.05.1989 US 19890352497 (71) Applicant: THE LIPOSOME COMPANY, INC. Princeton, NJ 08540 (US)

(72) Inventors: MADDEN, Thomas, D. Vancouver, British Columbia V6G 2E1 (CA) HOPE, Michael, J. Vancouver, British Columbia V6R 2K2 (CA) TILCOCK, Colin, P., S. Vancouver, British Columbia V6K 1E9 (CA) CULLIS, Pieter, R. Vancouver, British Columbia V6J 3R2 (CA) HARRIGAN, P., Richard Vancouver, British Columbia V6P 4M1 (CA) MUI, Barbara, S. Vancouver, British Columbia V6H 1M2 (CA) Bally, Marcel, B. Bowen Island, British Columbia V0N 1G0 (CA) TAI, Linda Vancouver, British Columbia V6K 1Y4 (CA) MAYER, Lawrence, D. Vancouver, British Columbia V6N 2P3 (CA) (74) Representative: Warcoin, Jacques, et al  Cabinet Régimbeau, 26, avenue Kléber F-75116 Paris F-75116 Paris (FR)