(19)

(11)

EP 0 473 701 A1

(12)

(43) Date of publication: 11.03.1992 Bulletin 1992/11 (21) Application number: 90908982.0 (22) Date of filing: 11.05.1990

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 3/ 00( . ) C07K 1/ 20( . ) C07K 14/ 435( . ) C07K 14/ 61( . ) C07K 19/ 00( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 38/ 23( . ) A61P 43/ 00( . ) C07K 14/ 00( . ) C07K 14/ 575( . ) C07K 14/ 635( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 16( . ) C12P 21/ 06( . ) (86) International application number: PCT/US1990/002650 (87) International publication number: WO 1990/014415 (29.11.1990 Gazette 1990/27)

(84) Designated Contracting States: DE FR GB (30) Priority: 12.05.1989 US 19890350979 (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)	(72) Inventors: KRONENBERG, Henry, M. Belmont, MA 02178 (US) NUSSBAUM, Samuel, R. Weston, MA 02193 (US) DOI, Tomoko Protein Engineering Research Institute Suita 565 (JP) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)