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(11)

EP 0 474 676 A1

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(43) Date of publication: 18.03.1992 Bulletin 1992/12 (21) Application number: 90908160.0 (22) Date of filing: 29.05.1990

(51) International Patent Classification (IPC):  C07K 14/ 08( . ) C12N 15/ 33( . ) C12N 15/ 81( . ) A61K 39/ 00( . ) C07K 16/ 10( . ) C12N 15/ 72( . ) A61K 38/ 00( . ) (86) International application number: PCT/AU1990/000224 (87) International publication number: WO 1990/015140 (13.12.1990 Gazette 1990/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 30.05.1989 AU 19890004469 (71) Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION Chatswood, NSW 2067 (AU)

(72) Inventors: AZAD, Ahmed, Abdulla Lower Templestowe, VIC 3107 (AU) MACREADIE, Ian, Geoffrey Templestowe, VIC 3106 (AU) McKERN, Neil, Moreton Lilydale, VIC 3140 (AU) VAUGHAN, Paul, Richard Rowville, VIC 3178 (AU) JAGADISH, Mittur, Nanjappa Gladstone Park, VIC 3043 (AU) FAHEY, Kevin, John Templestowe, VIC 3106 (AU) CHAPMAN, Antony, James Murrumbeena, VIC 3163 (AU) HEINE, Hans-Georg Coburg, VIC 3058 (AU) (74) Representative: Geering, Keith Edwin, et al  REDDIE & GROSE 16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)