(19)

(11)

EP 0 474 728 A1

(12)

(43) Date of publication: 18.03.1992 Bulletin 1992/12 (21) Application number: 90908828.0 (22) Date of filing: 23.05.1990

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/US1990/002729 (87) International publication number: WO 1990/015156 (13.12.1990 Gazette 1990/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 31.05.1989 US 19890358808 (71) Applicant: TEMPLE UNIVERSITY Philadelphia Pennsylvania 19122 (US)	(72) Inventor: CROCE, Carlo, M. Philadelphia, PA 19103 (US) (74) Representative: Bannerman, David Gardner  Withers & Rogers 4 Dyer's Buildings Holborn London, EC1N 2JT London, EC1N 2JT (GB)