(19)

(11)

EP 0 475 992 A1

(12)

(43) Date of publication: 25.03.1992 Bulletin 1992/13 (21) Application number: 90908589.0 (22) Date of filing: 05.06.1990

(51) International Patent Classification (IPC):  A61K 31/ 70( . ) A61K 31/ 7052( . ) A61K 31/ 7072( . ) C07H 19/ 06( . ) C07H 19/ 10( . ) A61K 31/ 7042( . ) A61K 31/ 7064( . ) A61P 31/ 12( . ) C07H 19/ 09( . ) (86) International application number: PCT/GB1990/000867 (87) International publication number: WO 1990/015064 (13.12.1990 Gazette 1990/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 06.06.1989 GB 19890012972 (71) Applicant: THE WELLCOME FOUNDATION LIMITED London NW1 2BP (GB)	(72) Inventors: RAHIM, Saad, George Beckenham Kent BR3 3BS (GB) POWELL, Kenneth Beckenham Kent BR3 3BS (GB) (74) Representative: Garrett, Michael  The Wellcome Foundation Limited Group Patents and Agreements Langley Court Beckenham Kent BR3 3BS Beckenham Kent BR3 3BS (GB)