(19)

(11)

EP 0 477 289 A1

(12)

(43) Date of publication: 01.04.1992 Bulletin 1992/14 (21) Application number: 90910225.0 (22) Date of filing: 08.06.1990

(51) International Patent Classification (IPC):  A61K 9/ 107( . ) A61K 31/ 19( . ) A61K 31/ 55( . ) A61K 47/ 44( . ) A61K 9/ 00( . ) A61K 31/ 38( . ) A61K 31/ 70( . ) (86) International application number: PCT/US1990/003250 (87) International publication number: WO 1991/008734 (27.06.1991 Gazette 1991/14)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 13.06.1989 US 19890365409 (71) Applicant: ABBOTT LABORATORIES Abbott Park, Illinois 60064-3500 (US)	(72) Inventors: ADJEI, Akwete, L. Wadsworth, IL 60083 (US) BORODKIN, Saul Libertyville, IL 60048 (US) DOYLE, Richard, B. Round Lake Beach, IL 60073 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano & Associati S.r.l. Via Meravigli, 16 I-20123 Milano I-20123 Milano (IT)