(19)

(11)

EP 0 477 307 A1

(12)

(43) Date of publication: 01.04.1992 Bulletin 1992/14 (21) Application number: 91905328.0 (22) Date of filing: 15.02.1991

(51) International Patent Classification (IPC):  A61K 38/ 16( . ) C12N 5/ 02( . ) (86) International application number: PCT/US1991/001028 (87) International publication number: WO 1991/012818 (05.09.1991 Gazette 1991/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 23.02.1990 US 19900484514 (71) Applicant: IMMULOGIC PHARMACEUTICAL CORPORATION Cambridge Massachusetts 02139 (US)	(72) Inventors: LAMB, Jonathan, Robert London W5 15D (GB) O'HEHIR, Robyn Elizabeth London NW2 4EP (GB) (74) Representative: Glawe, Delfs, Moll & Partner  Patentanwälte Postfach 26 01 62 D-80058 München D-80058 München (DE)