(19)

(11)

EP 0 477 345 A1

(12)

(43) Date of publication: 01.04.1992 Bulletin 1992/14 (21) Application number: 91908304.0 (22) Date of filing: 27.03.1991

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61P 29/ 00( . ) C07K 1/ 20( . ) C07K 14/ 52( . ) C12P 21/ 00( . ) C12R 1/ 91( . ) A61P 11/ 00( . ) A61P 37/ 06( . ) C07K 14/ 435( . ) C07K 16/ 00( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1991/002136 (87) International publication number: WO 1991/015223 (17.10.1991 Gazette 1991/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 30.03.1990 US 19900502318 (71) Applicants: AMGEN INC. Thousand Oaks California 91320 -1789 (US) CORNELL RESEARCH FOUNDATION, INC. Ithaca, NY 14850 (US)	(72) Inventors: NARACHI, Michael, A. Ventura, CA 93001 (US) ARAKAWA, Tsutomu Thousand Oaks, CA 91360 (US) NATHAN, Carl, F. Larchmont, NY 10538 (US) SRIMAL, Subita New York, NY 10028 (US) (74) Representative: Brown, John David, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)