(19)
(11) EP 0 478 546 A1

(12)

(43) Date of publication:
08.04.1992 Bulletin 1992/15

(21) Application number: 89912063.0

(22) Date of filing: 13.10.1989
(51) International Patent Classification (IPC): 
C07D 473/ 04( . )
A61K 31/ 52( . )
A61P 35/ 00( . )
C07D 473/ 20( . )
C07D 473/ 28( . )
C07D 473/ 36( . )
C07D 473/ 40( . )
A61K 31/ 505( . )
A61K 31/ 522( . )
A61P 39/ 02( . )
C07D 473/ 22( . )
C07D 473/ 30( . )
C07D 473/ 38( . )
C07D 487/ 04( . )
(86) International application number:
PCT/US1989/004634
(87) International publication number:
WO 1990/004966 (17.05.1990 Gazette 1990/11)
(84) Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE

(30) Priority: 26.10.1988 US 19880262880

(71) Applicant: BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
Austin, Texas 78701 (US)

(72) Inventor:
  • MACLEOD, Michael, C.
    Austin, TX 78741 (US)

(74) Representative: Dost, Wolfgang, Dr. rer.nat., Dipl.-Chem., et al 
Bardehle, Pagenberg & Partner, Galileiplatz 1
D-81679 München
D-81679 München (DE)

   


(54) CHEMOPREVENTION OF ELECTROPHILIC DAMAGE BY MERCAPTOPURINE ANALOGS