(19)
(11)
EP 0 478 546 A1
(12)
(43)
Date of publication:
08.04.1992
Bulletin 1992/15
(21)
Application number:
89912063.0
(22)
Date of filing:
13.10.1989
(51)
International Patent Classification (IPC):
C07D
473/
04
( . )
A61K
31/
52
( . )
A61P
35/
00
( . )
C07D
473/
20
( . )
C07D
473/
28
( . )
C07D
473/
36
( . )
C07D
473/
40
( . )
A61K
31/
505
( . )
A61K
31/
522
( . )
A61P
39/
02
( . )
C07D
473/
22
( . )
C07D
473/
30
( . )
C07D
473/
38
( . )
C07D
487/
04
( . )
(86)
International application number:
PCT/US1989/004634
(87)
International publication number:
WO 1990/004966
(
17.05.1990
Gazette 1990/11)
(84)
Designated Contracting States:
AT BE CH DE FR GB IT LI LU NL SE
(30)
Priority:
26.10.1988
US 19880262880
(71)
Applicant:
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
Austin, Texas 78701 (US)
(72)
Inventor:
MACLEOD, Michael, C.
Austin, TX 78741 (US)
(74)
Representative:
Dost, Wolfgang, Dr. rer.nat., Dipl.-Chem., et al
Bardehle, Pagenberg & Partner, Galileiplatz 1
D-81679 München
D-81679 München (DE)
(54)
CHEMOPREVENTION OF ELECTROPHILIC DAMAGE BY MERCAPTOPURINE ANALOGS