(19)

(11)

EP 0 479 790 A1

(12)

(43) Date of publication: 15.04.1992 Bulletin 1992/16 (21) Application number: 90905915.0 (22) Date of filing: 09.04.1990

(51) International Patent Classification (IPC):  A61K 8/ 00( . ) A61K 8/ 41( . ) A61K 8/ 89( . ) A61Q 5/ 06( . ) A61K 8/ 34( . ) A61K 8/ 81( . ) A61K 8/ 891( . ) (86) International application number: PCT/US1990/001835 (87) International publication number: WO 1990/014072 (29.11.1990 Gazette 1990/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 22.05.1989 US 19890354870 (71) Applicant: ISP INVESTMENTS INC Wayne, New Jersey 07470-3687 (US)	(72) Inventors: CHUANG, Jui-Chang Wayne, NJ 07470 (US) WALLS, Edward, Jr. Cranford, NJ 07016 (US) JOHNSON, Stephen, C. Newton, NJ 07860 (US) TAZI, Mohammed Wayne, NJ 07470 (US) (74) Representative: Ford, Michael Frederick, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)