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EP 0 479 916 A1

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(43) Date of publication: 15.04.1992 Bulletin 1992/16 (21) Application number: 90911356.0 (22) Date of filing: 22.06.1990

(51) International Patent Classification (IPC):  C07K 14/ 00( . ) C07K 14/ 72( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) C07K 14/ 705( . ) C07K 19/ 00( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1990/003564 (87) International publication number: WO 1990/015815 (27.12.1990 Gazette 1990/29)

(84) Designated Contracting States: AT BE CH DE ES FR GB IT LI LU NL SE (30) Priority: 22.06.1989 US 19890370407 (71) Applicants: THE SALK INSTITUTE FOR BIOLOGICAL STUDIES La Jolla California 92038 (US) Sloan-Kettering Institute For Cancer Research New York, New York 10021 (US) TAKAKU, Fumimaro Tokyo (JP) IMAWARI, Michio Tokyo (JP) ISHIKAWA, Takashi San Francisco, CA 94122 (US) EVANS, Ronald Mark La Jolla, CA (US) UMESONO, Kazuhiko La Jolla, CA (US)

(72) Inventors: TAKAKU, Fumimaro Tokyo (JP) IMAWARI, Michio Tokyo (JP) ISHIKAWA, Takashi San Francisco, CA 94122 (US) EVANS, Ronald Mark La Jolla, CA 92037 (US) UMESONO, Kazuhiko La Jolla, CA 92037 (US) (74) Representative: Allard, Susan Joyce  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)