(19)

(11)

EP 0 482 061 A1

(12)

(43) Date of publication: 29.04.1992 Bulletin 1992/18 (21) Application number: 90910856.0 (22) Date of filing: 10.07.1990

(51) International Patent Classification (IPC):  A61K 39/ 205( . ) C07K 7/ 08( . ) C07K 14/ 07( . ) C12N 15/ 09( . ) C12N 15/ 863( . ) C07K 7/ 06( . ) C07K 14/ 00( . ) C12N 5/ 10( . ) C12N 15/ 39( . ) C12P 21/ 02( . ) (86) International application number: PCT/GB1990/001062 (87) International publication number: WO 1991/000911 (24.01.1991 Gazette 1991/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 11.07.1989 GB 19890015870 (71) Applicant: NATIONAL RESEARCH DEVELOPMENT CORPORATION London SE1 6BU (GB)	(72) Inventors: GAFFNEY, Dairena, Frances Glasgow G14 9EF (GB) PATEL, Arvind, Hirabhai Lanarkshire ML1 3BT (GB) STOW, Nigel, Dennis Glasgow G52 2SE (GB) SUBAK-SHARPE, John, Herbert Glasgow G12 9NH (GB) (74) Representative: Percy, Richard Keith  Patents Department British Technology Group Ltd 101 Newington Causeway London SE1 6BU London SE1 6BU (GB)