(19)

(11)

EP 0 482 125 A1

(12)

(43) Date of publication: 29.04.1992 Bulletin 1992/18 (21) Application number: 90917903.0 (22) Date of filing: 27.06.1990

(51) International Patent Classification (IPC):  C07K 4/ 08( . ) C12N 15/ 87( . ) C12M 3/ 00( . ) (86) International application number: PCT/US1990/003663 (87) International publication number: WO 1991/000915 (24.01.1991 Gazette 1991/03)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 11.07.1989 US 19890378256 (71) Applicant: BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION Peoria, IL 61604 (US)	(72) Inventor: METS, Laurens, J. Chicago, IL 60637 (US) (74) Representative: Dost, Wolfgang, Dr.rer.nat., Dipl.-Chem., et al  Patent- und Rechtsanwälte Bardehle . Pagenberg . Dost . Altenburg . Frohwitter . Geissler & Partner Postfach 86 06 20 D-81633 München D-81633 München (DE)