(19)

(11)

EP 0 482 144 A1

(12)

(43) Date of publication: 29.04.1992 Bulletin 1992/18 (21) Application number: 91907785.0 (22) Date of filing: 05.04.1991

(51) International Patent Classification (IPC):  A61K 38/ 55( . ) C07K 14/ 00( . ) C12N 1/ 21( . ) C12N 9/ 99( . ) C12N 15/ 15( . ) C12R 1/ 19( . ) A61P 7/ 02( . ) C07K 14/ 815( . ) C12N 5/ 10( . ) C12N 15/ 09( . ) A61K 38/ 00( . ) (86) International application number: PCT/EP1991/000643 (87) International publication number: WO 1991/017250 (14.11.1991 Gazette 1991/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI NL SE (30) Priority: 10.05.1990 GB 19900010552 (71) Applicant: FARMITALIA CARLO ERBA S.r.l. I-20159 Milano (IT)

(72) Inventors: BENATTI, Luca I-20093 Cologno Monzese (IT) CARMINATI, Paolo I-20131 Milan (IT) LANSEN, Jacqueline I-20159 Milan (IT) MAZUE, Guy I-20148 Milan (IT) RONCUCCI, Romeo I-20100 Milan (IT) SARMIENTOS, Paolo I-20149 Milan (IT) SCACHERI, Emanuela I-20100 Milan (IT) DE TAXIS DU POET, Philippe I-20100 Milan (IT) (74) Representative: Woods, Geoffrey Corlett, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)