(19)

(11)

EP 0 482 189 A1

(12)

(43) Date of publication: 29.04.1992 Bulletin 1992/18 (21) Application number: 91912612.0 (22) Date of filing: 07.05.1991

(51) International Patent Classification (IPC):  C07D 498/ 18( . ) C07K 1/ 22( . ) C07K 14/ 705( . ) G01N 33/ 53( . ) C07K 1/ 20( . ) C07K 14/ 00( . ) C07K 14/ 72( . ) G01N 33/ 94( . ) (86) International application number: PCT/US1991/003114 (87) International publication number: WO 1991/017439 (14.11.1991 Gazette 1991/26)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IT LI LU NL SE (30) Priority: 09.05.1990 US 19900521074 (71) Applicant: CHILDREN'S RESEARCH INSTITUTE Washington DC 20010 (US)	(72) Inventors: SOLDIN, Steven, J. Washington, DC 20015 (US) SOLDIN, Steven, J. Washington, DC 20015 (US) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)