(19)

(11)

EP 0 483 219 A1

(12)

(43) Date of publication: 06.05.1992 Bulletin 1992/19 (21) Application number: 90911082.0 (22) Date of filing: 02.07.1990

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61P 43/ 00( . ) C12N 5/ 10( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) C07K 14/ 82( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1990/003729 (87) International publication number: WO 1991/000287 (10.01.1991 Gazette 1991/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 30.06.1989 US 19890373864 (71) Applicant: THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Washington, DC 20002 (US)	(72) Inventors: HUGHES, Stephen, H. Smithsburg, MD 21783 (US) SUTRAVE, Pramod Frederick, MD 21701 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)