(19)

(11)

EP 0 483 226 A1

(12)

(43) Date of publication: 06.05.1992 Bulletin 1992/19 (21) Application number: 90911215.0 (22) Date of filing: 18.07.1990

(51) International Patent Classification (IPC):  C12M 1/ 18( . ) C12Q 1/ 00( . ) G01N 35/ 02( . ) G01N 35/ 10( . ) C12M 1/ 34( . ) G01N 1/ 28( . ) G01N 35/ 00( . ) (86) International application number: PCT/US1990/004025 (87) International publication number: WO 1991/001365 (07.02.1991 Gazette 1991/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 18.07.1989 US 19890382483 (71) Applicant: Oncogene Science, Inc. Manhasset New York 11030 (US)	(72) Inventors: PIELER, Christian Westbury, NY 11590 (US) LEICHTFRIED, Franz, E. Bellerose, NY 11001 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)