(19)

(11)

EP 0 483 281 A1

(12)

(43) Date of publication: 06.05.1992 Bulletin 1992/19 (21) Application number: 90912413.0 (22) Date of filing: 31.07.1990

(51) International Patent Classification (IPC):  C07K 16/ 00( . ) A61K 39/ 00( . ) C07K 16/ 40( . ) C12N 9/ 08( . ) C12N 15/ 09( . ) G01N 33/ 53( . ) A61K 38/ 00( . ) A61K 35/ 14( . ) C07K 14/ 00( . ) C12N 5/ 10( . ) C12N 15/ 02( . ) C12P 21/ 08( . ) G01N 33/ 573( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1990/004289 (87) International publication number: WO 1991/002061 (21.02.1991 Gazette 1991/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB IT LI LU NL SE (30) Priority: 31.07.1989 US 19890388044 30.01.1990 US 19900472070 (71) Applicant: RAPAPORT, Basil Greenbrae, CA 94904 (US)	(72) Inventor: RAPAPORT, Basil Greenbrae, CA 94904 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)